Biological processes have become a significant industry in constant growth. Development in the field of vaccines, antibodies and pharmaceuticals is very popular. The physiology of the cells used is very sensitive and requires quick adjustments to maintain accurate control of the culture media. Several parameters must be controlled; pH, dissolved oxygen, carbon dioxide and cell density. These needs are fulfilled by modern on-line measurement sensors. An important advancement towards on-line measurement is achieved with the new Incyte and Dencytee sensors from Hamilton.
CHO cells (Chinese Hamster Ovary) are used in bio-pharma for industrial production of monoclonal antibodies (among others) that are used for therapy and diagnosis purposes. Negative effects on the cells, and consequently on the productivity, must be avoided since the costs for mammalian cell cultivation is very high. In order to attain an economical production process, the most important parameters, such as the viable cell density, need to be measured. The Incyte Sensor of Hamilton Bonaduz AG is designed for exactly this purpose.